Epidemiology of Endocrine Disorders

Long-term treatment outcomes of acromegaly patients presenting biochemically-uncontrolled at a tertiary pituitary center

Acromegaly is a rare, slowly progressive disorder resulting from excessive growth hormone (GH) production by a pituitary somatotroph tumor. The objective of this study was to examine acromegaly treatment outco...

Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert

Clinicopathological features and prognosis of gastroenteropancreatic neuroendocrine neoplasms in a Chinese population: a large, retrospective single-centre study

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common type of neuroendocrine tumors, accounting for more than half of neuroendocrine neoplasms (NENs). We performed a retrospective stud...

Authors: Meng Zhang, Ping Zhao, Xiaodan Shi, Ahong Zhao, Lianfeng Zhang and Lin Zhou

Health-related quality of life in type-2 diabetes patients: a cross-sectional study in East China

Used the EuroQoL-5 dimension (EQ-5D) to evaluate the health status of 5310 residents who live in East China, and compared the health-related quality of life (HRQoL) with 311 patients with type 2 diabetes as we...

Authors: You Lu, Ningjian Wang, Yi Chen, Xiaomin Nie, Qin Li, Bing Han, Yingchao Chen, Fangzhen Xia, Zhen Cang, Meng Lu, Ying Meng and Yingli Lu

Factors associated with diabetes-related distress over time among patients with T2DM in a tertiary hospital in Singapore

Persistent diabetes-related distress (DRD) is experienced by patients with Type 2 Diabetes Mellitus. Knowing factors associated with persistent DRD will aid clinicians in prioritising interventions efforts.

Authors: Maudrene L. Tan, Chuen S. Tan, Konstadina Griva, Yung S. Lee, Jeannette Lee, E. S. Tai, Eric Y. Khoo and Hwee-Lin Wee

Factors associated with impaired color vision without retinopathy amongst people with type 2 diabetes mellitus: a cross-sectional study

Patients with type 2 diabetes mellitus (T2DM) may develop color vision impairment. This study aimed to determine the prevalence and factors associated with impaired color vision in patients with T2DM but witho...

Authors: N. C. Tan, W. F. Yip, S. Kallakuri, U. Sankari and Y. L. E. Koh

Age differences in diabetes-related complications and glycemic control

This study aimed to examine the associations of age with the presence of complications and glycemic control in the Northwest of Iran.

Authors: S. M. Shamshirgaran, A. Mamaghanian, A. Aliasgarzadeh, N. Aiminisani, M. Iranparvar-Alamdari and J. Ataie

The incidence of diabetes mellitus and diabetic retinopathy in a population-based cohort study of people age 50 years and over in Nakuru, Kenya

The epidemic rise of diabetes carries major negative public health and economic consequences particularly for low and middle-income countries. The highest predicted percentage growth in diabetes is in the sub-...

Authors: Andrew Bastawrous, Wanjiku Mathenge, Kevin Wing, Madeleine Bastawrous, Hillary Rono, Helen A. Weiss, David Macleod, Allen Foster, Tunde Peto, Peter Blows, Matthew Burton and Hannah Kuper

Impaired lung function is associated with non-alcoholic fatty liver disease independently of metabolic syndrome features in middle-aged and elderly Chinese

Associations between lung function and non-alcoholic fatty liver disease (NAFLD) have been reported. However, evidence from large-scale populations about the relationship is scarce. The objective of the study ...

Authors: Li Qin, Weiwei Zhang, Zhen Yang, Yixin Niu, Xiaoyong Li, Shuai Lu, Yin Xing, Ning Lin, Hongmei Zhang, Guang Ning, Jiangao Fan and Qing Su

Prevalence and determinants of erectile dysfunction among diabetic patients attending in hospitals of central and northwestern zone of Tigray, northern Ethiopia: a cross-sectional study

The prevalence of erectile dysfunction among diabetic men varies between 35–90%. Although erectile dysfunction is widespread among men with diabetes, the condition often remains undiagnosed and demands appropr...

Authors: Awole Seid, Hadgu Gerensea, Shambel Tarko, Yosef Zenebe and Rahel Mezemir

The association between biochemical control and cardiovascular risk factors in acromegaly

The study aim was to estimate the proportion of acromegaly patients with various comorbidities and to determine if biochemical control was associated with reduced proportion of cardiovascular risk factors.

Authors: John D. Carmichael, Michael S. Broder, Dasha Cherepanov, Eunice Chang, Adam Mamelak, Qayyim Said, Maureen P. Neary and Vivien Bonert

Quality of sleep and risk for obstructive sleep apnoea in ambulant individuals with type 2 diabetes mellitus at a tertiary referral hospital in Kenya: a cross-sectional, comparative study

Sleep disorders are common and associated with multiple metabolic and psychological derangements. Obstructive sleep apnoea (OSA) is among the most common sleep disorders and an inter-relationship between OSA, ...

Authors: Sairabanu Mohammed Rashid Sokwalla, Mark David Joshi, Erastus Olonde Amayo, Kirtida Acharya, Jared Ongechi Mecha and Kenneth Kipyegon Mutai

Study protocol; Thyroid hormone Replacement for Untreated older adults with Subclinical hypothyroidism - a randomised placebo controlled Trial (TRUST)

Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the...

Authors: David J. Stott, Jacobijn Gussekloo, Patricia M. Kearney, Nicolas Rodondi, Rudi G. J. Westendorp, Simon Mooijaart, Sharon Kean, Terence J. Quinn, Naveed Sattar, Kirsty Hendry, Robert Du Puy, Wendy P. J. Den Elzen, Rosalinde K. E. Poortvliet, Jan W. A. Smit, J. Wouter Jukema, Olaf M. Dekkers…

Obesity and diabetes mellitus association in rural community of Katana, South Kivu, in Eastern Democratic Republic of Congo: Bukavu Observ Cohort Study Results

Factual data exploring the relationship between obesity and diabetes mellitus prevalence from rural areas of sub-Saharan Africa remain scattered and are unreliable. To address this scarceness, this work report...

Authors: Philippe Bianga Katchunga, Justin Cikomola, Christian Tshongo, Arsene Baleke, David Kaishusha, Patrick Mirindi, Théodore Tamburhe, Yves Kluyskens, Antoine Sadiki, Socrate Bwanamudogo, Zacharie Kashongwe and Marc Twagirumukiza

Arterial stiffness in hypertensive and type 2 diabetes patients in Ghana: comparison of the cardio-ankle vascular index and central aortic techniques

Diabetes and hypertension increase arterial stiffness and cardiovascular events in all societies studied so far; sub-Saharan African studies are sparse. We investigated factors affecting arterial function in G...

Authors: Kwame Yeboah, Daniel A. Antwi, Ben Gyan, Virginia Govoni, Charlotte E. Mills, J. Kennedy Cruickshank and Albert G. B. Amoah

Prevalence of impaired glucose tolerance and other types of dysglycaemia among young twins and singletons in Guinea-Bissau

Twins may be at increased risk of dysglycaemic disorders due to adverse fetal conditions. Data from Africa regarding this association is limited. We studied impaired glucose tolerance (IGT) and other types of ...

Authors: Ditte Egegaard Hennild, Morten Bjerregaard-Andersen, Luis Carlos Joaquím, Kaare Christensen, Morten Sodemann, Henning Beck-Nielsen and Dorte Møller Jensen

Association of blood glucose level and hypertension in Elderly Chinese Subjects: a community based study

There is a scarcity of epidemiological researches examining the relationship between blood pressure (BP) and glucose level among older adults. The objective of the current study was to investigate the associat...

Authors: Qun Yan, Dongmei Sun, Xu Li, Guoliang Chen, Qinghu Zheng, Lun Li, Chenhong Gu and Bo Feng

Diabetes related knowledge, self-care behaviours and adherence to medications among diabetic patients in Southwest Ethiopia: a cross-sectional survey

The provision of health education involving self-care and good adherence to medications has been acknowledged to be a cost effective strategy for improving quality of life of diabetes patients. We assessed lev...

Authors: Tefera Kassahun, Hailay Gesesew, Lillian Mwanri and Tesfahun Eshetie

Metabolic syndrome and osteoporotic fracture: a population-based study in China

Associations between metabolic syndrome (MetS) and osteoporotic fracture have been reported. However, the epidemiological studies are not conclusive. The objective of the study was to determine whether metabol...

Authors: Li Qin, Zhen Yang, Weiwei Zhang, Hongxia Gu, Xiaoyong Li, Lingfei Zhu, Shuai Lu, Yin Xing, Hongmei Zhang, Yixin Niu, Guang Ning and Qing Su

Understanding adherence-related beliefs about medicine amongst patients of South Asian origin with diabetes and cardiovascular disease patients: a qualitative synthesis

Prevalence of diabetes and cardiovascular (CVD) disease amongst UK South Asians is higher than in the general population. Non-adherence to medicines may lead to poor clinical outcomes for South Asian patients ...

Authors: Kanta Kumar, Sheila Greenfield, Karim Raza, Paramjit Gill and Rebecca Stack

Cost effectiveness and value of information analyses of islet cell transplantation in the management of ‘unstable’ type 1 diabetes mellitus

Islet cell transplantation is a method to stabilize type 1 diabetes patients with hypoglycemia unawareness and unstable blood glucose levels by reducing insulin dependency and protecting against severe hypogly...

Authors: Klemens Wallner, A. M. James Shapiro, Peter A. Senior and Christopher McCabe

Is thyroid status associated with cognitive impairment in elderly patients in China?

The relationship between alterations in thyroid function and cognitive deficits has been investigated in several previous studies. Hypo-or hyperthyroidism and, to a lesser extent, subclinical thyroid dysfuncti...

Authors: Yao Hu, Zhi-cheng Wang, Qi-hao Guo, Wei Cheng and Yan-wen Chen

A null mutation in ANGPTL8 does not associate with either plasma glucose or type 2 diabetes in humans

Experiments in mice initially suggested a role for the protein angiopoietin-like 8 (ANGPTL8) in glucose homeostasis. However, subsequent experiments in model systems have challenged this proposed role. We soug...

Authors: Katharine R. Clapham, Audrey Y. Chu, Jennifer Wessel, Pradeep Natarajan, Jason Flannick, Manuel A. Rivas, Samantha Sartori, Roxana Mehran, Usman Baber, Valentin Fuster, Robert A. Scott, Daniel J. Rader, Michael Boehnke, Mark I. McCarthy, David M. Altshuler, Sekar Kathiresan…

Erratum to: Association of environmental chemicals & estrogen metabolites in children

Authors: Erin Speiser Ihde, Ji Meng Loh and Lawrence Rosen

High prevalence of metabolic syndrome in a mestizo group of adult patients with primary hyperparathyroidism (PHPT)

Primary hyperparathyroidism (PHPT) and metabolic syndrome (MS) have been independently related to cardiovascular morbidities, however this association is still controversial. Mexican population has a high prev...

Authors: Victoria Mendoza-Zubieta, Gloria A Gonzalez-Villaseñor, Guadalupe Vargas-Ortega, Baldomero Gonzalez, Claudia Ramirez-Renteria, Moises Mercado, Mario A Molina-Ayala and Aldo Ferreira-Hermosillo

The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol

Children whose mothers had low thyroid hormone levels during pregnancy have been reported to have decreased cognitive function. The reported research is part of the follow-on study of the Controlled Antenatal ...

Authors: Charlotte Hales, Sue Channon, Peter N Taylor, Mohd S Draman, Ilaria Muller, John Lazarus, Ruth Paradice, Aled Rees, Dionne Shillabeer, John W Gregory, Colin M Dayan and Marian Ludgate

Insufficient early detection of peripheral neurovasculopathy and associated factors in rural diabetes residents of Taiwan: a cross-sectional study

Diabetic peripheral neuropathy (PN) and peripheral vasculopathy (PV) are major causes of foot ulcers in patients with diabetes. The early detection of PN/PV with appropriate health counseling is the best strat...

Authors: Chia-Mou Lee, Chang-Cheng Chang, Mei-Yu Pan, Chyong-Fang Chang and Mei-Yen Chen

A pattern of unspecific somatic symptoms as long-term premonitory signs of type 2 diabetes: findings from the population-based MONICA/KORA cohort study, 1984-2009

Unspecific symptoms often proceed a serious chronic disease condition long before the onset of the disease. The role of an unspecific premonitory symptom (UPMS) pattern as premonitory signs of subsequent type ...

Authors: Jens Baumert, Christa Meisinger, Karoline Lukaschek, Rebecca Thwing Emeny, Ina-Maria Rückert, Johannes Kruse and Karl-Heinz Ladwig

Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol a in polycystic ovary syndrome: a case–control study

Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder that affects approximately 6-10% of women of child-bearing age. Although preliminary studies suggest that certain pollutants may act as endoc...

Authors: Sara J Vagi, Eduardo Azziz-Baumgartner, Andreas Sjödin, Antonia M Calafat, Daniel Dumesic, Leonardo Gonzalez, Kayoko Kato, Manori J Silva, Xiaoyun Ye and Ricardo Azziz

Relationship between social determinants of health and processes and outcomes in adults with type 2 diabetes: validation of a conceptual framework

The aim of this study was to empirically validate a conceptual framework and elucidate the pathways linking social determinants of health to outcomes in individuals with type 2 diabetes.

Authors: Rebekah J Walker, Mulugeta Gebregziabher, Bonnie Martin-Harris and Leonard E Egede

A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria

Familial Hyperparathyroidism (HPT) and Familial benign Hypocalciuric Hypercalcemia (FHH) are the most common causes of hereditary hypercalcemia. FHH has been demonstrated to be caused by inactivating mutations...

Authors: Eugenio Mastromatteo, Olga Lamacchia, Michela Rosaria Campo, Antonella Conserva, Filomena Baorda, Luigia Cinque, Vito Guarnieri, Alfredo Scillitani and Mauro Cignarelli

A descriptive study of adrenal crises in adults with adrenal insufficiency: increased risk with age and in those with bacterial infections

An adrenal crisis (AC) is a major cause of morbidity in hypoadrenal patients. However, there is little information available on the incidence and underlying causes of AC.

Authors: R Louise Rushworth and David J Torpy

Prevalence and predictors of metabolic abnormalities in Chinese women with PCOS: a cross- sectional study

Polycystic ovary syndrome (PCOS) is a common condition estimated to affect 5.61% of Chinese women of reproductive age, but little is known about the prevalence and predictors in Chinese PCOS patients. This stu...

Authors: Rong Li, Geng Yu, Dongzi Yang, Shangwei Li, Shulan Lu, Xiaoke Wu, Zhaolian Wei, Xueru Song, Xiuxia Wang, Shuxin Fu and Jie Qiao

Lifestyle and clinical factors associated with elevated C-reactive protein among newly diagnosed Type 2 diabetes mellitus patients: a cross-sectional study from the nationwide DD2 cohort

We aimed to examine the prevalence of and modifiable factors associated with elevated C-reactive Protein (CRP), a marker of inflammation, in men and women with newly diagnosed Type 2 Diabetes mellitus (DM) in ...

Authors: Elisabeth Svensson, Anil Mor, Jørgen Rungby, Klara Berencsi, Jens Steen Nielsen, Jacob V Stidsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Henning Beck-Nielsen, Henrik Toft Sørensen and Reimar W Thomsen

Antihyperglycaemic treatment patterns, observed glycaemic control and determinants of treatment change among patients with type 2 diabetes in the United Kingdom primary care: a retrospective cohort study

The initial treatment strategy for patients with type 2 diabetes includes lifestyle change recommendations. When patients are not successful in controlling their blood glucose levels through healthier lifestyl...

Authors: Andrew Maguire, Beth D Mitchell and Javier Cid Ruzafa

Characteristics and effectiveness of diabetes self-management educational programs targeted to racial/ethnic minority groups: a systematic review, meta-analysis and meta-regression

It is not clear to what extent educational programs aimed at promoting diabetes self-management in ethnic minority groups are effective. The aim of this work was to systematically review the effectiveness of e...

Authors: Ignacio Ricci-Cabello, Isabel Ruiz-Pérez, Antonio Rojas-García, Guadalupe Pastor, Miguel Rodríguez-Barranco and Daniela C Gonçalves

Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum

α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu a...

Authors: Eric D Gaier, Alison Kleppinger, Martina Ralle, Jonathan Covault, Richard E Mains, Anne M Kenny and Betty A Eipper

Clinical, pathological and prognostic characteristics of gastroenteropancreatic neuroendocrine neoplasms in China: a retrospective study

Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are rare neuroendocrine tumors, and lack of data in Asian populations especially in China. The aim of this retrospective study was to assess the clini...

Authors: Xianbin Zhang, Li Ma, Haidong Bao, Jing Zhang, Zhongyu Wang and Peng Gong

Contrasting effects of preexisting hyperglycemia and higher body size on hospital mortality in critically ill patients: a prospective cohort study

Obesity and diabetes mellitus are well-defined risk factors for cardiovascular mortality. The impact of antecedent hyperglycemia and body size on mortality in critical ill patients in intensive care units (ICU...

Authors: Marina Verçoza Viana, Rafael Barberena Moraes, Amanda Rodrigues Fabbrin, Manoella Freitas Santos, Vanessa Bielefeldt Leotti Torman, Silvia Regina Vieira, Jorge Luiz Gross, Luis Henrique Canani and Fernando Gerchman

Hypoglycaemia, chronic kidney disease and death in type 2 diabetes: the Hong Kong diabetes registry

In patients with type 2 diabetes, chronic kidney disease (CKD) is associated with increased risk of hypoglycaemia and death. Yet, it remains uncertain whether hypoglycaemia-associated mortality is modified by ...

Authors: Alice PS Kong, Xilin Yang, Andrea Luk, Kitty KT Cheung, Ronald CW Ma, Wing Yee So, Chung Shun Ho, Michael HM Chan, Risa Ozaki, Chun Chung Chow, Nicola Brown and Juliana CN Chan

Increased waist circumference is independently associated with hypothyroidism in Mexican Americans: replicative evidence from two large, population-based studies

Mexican Americans are at an increased risk of both thyroid dysfunction and metabolic syndrome (MS). Thus it is conceivable that some components of the MS may be associated with the risk of thyroid dysfunction ...

Authors: Manju Mamtani, Hemant Kulkarni, Thomas D Dyer, Laura Almasy, Michael C Mahaney, Ravindranath Duggirala, Anthony G Comuzzie, Paul B Samollow, John Blangero and Joanne E Curran

Epidemiology and costs of diabetes mellitus in Switzerland: an analysis of health care claims data, 2006 and 2011

Quantifying the burden of diabetes mellitus is fundamental for managing patients in health service delivery systems and improves the understanding of the importance of prevention and early intervention of diab...

Authors: Carola A Huber, Matthias Schwenkglenks, Roland Rapold and Oliver Reich

Testicular histological and immunohistochemical aspects in a post-pubertal patient with 5 alpha-reductase type 2 deficiency: case report and review of the literature in a perspective of evaluation of potential fertility of these patients

Testicular morphology and immunohistochemical studies have never been reported in genetically documented adult patients with 5 alpha-reductase type 2 deficiency (5α-R2 deficiency).

Authors: Lavinia Vija, Sophie Ferlicot, Diana Paun, Hélène Bry-Gauillard, Gabriela Berdan, Issam Abd-Alsamad, Marc Lombès and Jacques Young

European Adrenal Insufficiency Registry (EU-AIR): a comparative observational study of glucocorticoid replacement therapy

Increased morbidity and mortality associated with conventional glucocorticoid replacement therapy for primary adrenal insufficiency (primary AI; estimated prevalence 93–140/million), secondary AI (estimated pr...

Authors: Bertil Ekman, David Fitts, Claudio Marelli, Robert D Murray, Marcus Quinkler and Pierre MJ Zelissen

Prevalence and determinants of osteoporosis in patients with type 1 and type 2 diabetes mellitus

Increased risk of osteoporosis and its clinical significance in patients with diabetes is controversial. We analyze osteoporosis prevalence and determinants of bone mineral density (BMD) in patients with type ...

Authors: Gudrun Leidig-Bruckner, Sonja Grobholz, Thomas Bruckner, Christa Scheidt-Nave, Peter Nawroth and Jochen G Schneider

Association of blood manganese level with diabetes and renal dysfunction: a cross-sectional study of the Korean general population

The purpose of this study was to evaluate the association between blood manganese levels and the prevalence of chronic diseases in the Korean population.

Authors: Eun Sil Koh, Sung Jun Kim, Hye Eun Yoon, Jong Hee Chung, Sungjin Chung, Cheol Whee Park, Yoon Sik Chang and Seok Joon Shin

Retinopathy among young adults with Diabetes Mellitus from a tertiary care setting in Sri Lanka

Diabetic retinopathy (DR) is one of the leading causes for complete loss of vision among working-aged adults around the world. The present study aims to evaluate the rate of DR and its risk factors among the a...

Authors: Prasad Katulanda, Yasindu C Waniganayake, Priyanga Ranasinghe, WM Udai Akalanka Wijetunga, Mahesh Jayaweera, Nishantha P Wijesinghe, Rezvi Sheriff and David R Matthews

Association between metabolic syndrome and bone fractures: a meta-analysis of observational studies

Emerging epidemiological evidence suggest an association between metabolic syndrome and fractures. However, whether metabolic syndrome is an independent risk or protective factor of fractures remains controver...

Authors: Kan Sun, Jianmin Liu, Nan Lu, Hanxiao Sun and Guang Ning

Takotsubo cardiomyopathy and transient thyrotoxicosis during combination therapy with interferon-alpha and ribavirin for chronic hepatitis C

Thyroid dysfunction is a common complication of chronic hepatitis C (CHC) and its therapy. Takotsubo cardiomyopathy (TCM) is a multifactorial, stress related cardiomyopathy, rarely reported in association with th...

Authors: Carmen Sorina Martin, Luminita Nicoleta Ionescu, Carmen Gabriela Barbu, Anca Elena Sirbu, Ioana Maria Lambrescu, Ioana Smarandita Lacau, Doina Ruxandra Dimulescu and Simona Vasilica Fica

The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies

Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims to gain insights into the conseque...

Authors: Jana V van Vliet-Ostaptchouk, Marja-Liisa Nuotio, Sandra N Slagter, Dany Doiron, Krista Fischer, Luisa Foco, Amadou Gaye, Martin Gögele, Margit Heier, Tero Hiekkalinna, Anni Joensuu, Christopher Newby, Chao Pang, Eemil Partinen, Eva Reischl, Christine Schwienbacher…

Age-related bone turnover markers and osteoporotic risk in native Chinese women

The rate of bone turnover is closely related to osteoporosis risk. We investigated the correlation between bone turnover markers and BMD at various skeletal sites in healthy native Chinese women, and to study ...

Authors: Xi-Yu Wu, Hong-Li Li, Hui Xie, Xiang-Hang Luo, Yi-Qun Peng, Ling-Qing Yuan, Zhi-Feng Sheng, Ru-Chun Dai, Xian-Ping Wu and Er-Yuan Liao