Table 4 The enriched GO terms of the up and down regulated differentially expressed genes
From: Identification of hub genes related to the progression of type 1 diabetes by computational analysis
| GO ID | CATEGORY | GO Name | P Value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
|---|---|---|---|---|---|---|---|---|
| Up regulated genes | ||||||||
| GO:0007267 | BP | cell-cell signaling | 6.48E-03 | 1.84E-01 | 1.00E+00 | 1.00E+00 | 22 | TRHDE,NPBWR1,MYH6,AVP,PPFIA2,IL17B,PCDHB10,PCDHB2,GRIA4,GRIN2B,DCC,RGS4,PTHLH,CRHR2,GJA1,CSNK1A1L,DKK1,EGFR,SNAP91,RIMS4,LRP2,CCL13 |
| GO:0022414 | BP | reproductive process | 1.22E-02 | 1.99E-01 | 1.00E+00 | 1.00E+00 | 19 | NPPC,AVP,BTBD18,MEIOB,RAD21L1,TEX15,PTHLH,GJA1,EGFR,SPATA16,MIF,OSR1,LRP2,HFM1,ACSBG2,SPATA22,ATP1A4,PRL,UTF1 |
| GO:0005887 | CC | integral component of plasma membrane | 1.14E-03 | 1.17E-01 | 7.35E-01 | 3.43E-01 | 22 | TRHDE,SEMA6B,RDH8,NPBWR1,TMC2,TRHR,GPR37,PCDHB10,PCDHB2,TM4SF5,GRIA4,GRIN2B,DCC,KCNK4,PTPRT,CRHR2,ADGRL4,GJA1,EGFR,LRFN5,UPK1B,ATP1A4 |
| GO:0099512 | CC | supramolecularfiber | 1.65E-02 | 1.84E-01 | 1.00E+00 | 1.00E+00 | 17 | ABRA,DNAH3,MYH6,MYOT,NRAP,TMC2,MYH13,KIF1A,GRIN2B,GJA1,KRT39,MFAP2,TRIM55,LRP2,KRT20,KRT38,PTPN20 |
| GO:0038023 | MF | signaling receptor activity | 1.59E-03 | 1.30E-01 | 8.79E-01 | 7.75E-01 | 22 | OR2T29,NPBWR1,MYOT,TRHR,GPR37,OR10J3,GRIA4,GRIN2B,DCC,PTPRT,CRHR2,ADGRL4,MTRNR2L1,OR51E2,MTRNR2L6,OR51E1,DKK1,EGFR,OR6C70,LRP2,ADGRF4,FCAMR |
| GO:0005198 | MF | structural molecule activity | 3.67E-02 | 2.51E-01 | 1.00E+00 | 1.00E+00 | 10 | MYOT,EPB41L4B,MRPL12,PPFIA2,EMILIN3,KRT39,MFAP2,UPK1B,KRT20,KRT38 |
| Down regulated genes | ||||||||
| GO:0006906 | BP | vesicle fusion | 1.55E-04 | 7.94E-02 | 6.71E-01 | 4.06E-01 | 17 | CRISPLD2,DSP,RIMS3,OSCAR,SIGLEC14,DYSF,ITGAX,ITIH4,GAB2,LGALS9,MMP25,IGF2R,SCAMP5,TLN1,ADGRE5,TNFAIP2,CLEC4C |
| GO:0022610 | BP | biological adhesion | 2.52E-03 | 2.18E-01 | 1.00E+00 | 1.00E+00 | 19 | CDKN2A,MYADM,DSP,HLA-DQA1,LAG3,SIGLEC14,DYSF,ITGAX,TNFRSF21,LGALS9,SLC9A1,TLN1,NECTIN1,SORBS3,AOC3,PLXNA4,PXN,ADGRE5,PLXNA2 |
| GO:0098805 | CC | whole membrane | 4.42E-03 | 1.66E-01 | 1.00E+00 | 1.00E+00 | 21 | VPS37C,MYADM,HIP1,TPCN2,DSP,HLA-DQA1,SIGLEC14,GABARAP,DYSF,ITGAX,MICALL1,MMP25,ARHGAP1,SLC9A1,IGF2R,ATP6V0D1,SCAMP5,PRKACA,ADGRE5,CLEC4C,ATG16L2 |
| GO:0030054 | CC | cell junction | 2.83E-02 | 3.05E-01 | 1.00E+00 | 1.00E+00 | 15 | MYADM,DSP,ARHGEF5,RIMS3,LASP1,SLC9A1,IGF2R,SCAMP5,TLN1,NECTIN1,SORBS3,PXN,ADGRE5,ALKBH6,PDZD3 |
| GO:0008289 | MF | lipid binding | 2.91E-03 | 1.08E-01 | 7.31E-01 | 1.00E+00 | 13 | HIP1,CPNE9,ARHGEF5,PAQR6,APOL1,DYSF,GAB2,MICALL1,SLC9A1,IGF2R,ARAP3,TLN1,APOL2 |
| GO:0051020 | MF | GTPase binding | 5.51E-03 | 1.08E-01 | 7.31E-01 | 1.00E+00 | 10 | ARHGEF5,RGL3,RIMS3,MICALL1,ARHGAP1,PRKACA,DAAM2,RIPOR1,RGL2,RAPGEFL1 |