Table 3 The enriched pathway terms of the up and down regulated differentially expressed genes
From: Identification of hub genes related to the progression of type 1 diabetes by computational analysis
| Pathway ID | Pathway Name | P-value | FDR B&H | FDR B&Y | Bonferroni | Gene Count | Gene |
|---|---|---|---|---|---|---|---|
| Up regulated genes | |||||||
| 1,269,543 | Signaling by GPCR | 3.16E-03 | 1.94E-01 | 1.00E+00 | 7.89E-01 | 16 |
OR2T29,NPBWR1,TRHR,AVP,GPR37,OR10J3,GRIN2B, RGS4,PTHLH,CRHR2, OR51E2,OR51E1,EGFR,OR6C70, CCL13,CCL19 |
| 1,269,868 | Muscle contraction | 5.98E-03 | 1.94E-01 | 1.00E+00 | 1.00E+00 | 5 | MYH6,NPPC,KCNK4,ATP1A4,PLN |
| 1,269,958 | Digestion of dietary carbohydrate | 5.00E-02 | 2.98E-01 | 1.00E+00 | 1.00E+00 | 1 | AMY1A |
| 1,457,790 | Keratinization | 1.22E-01 | 1.00E+00 | 3.53E-01 | 1.00E+00 | 3 | KRT39,KRT20,KRT38 |
| 1,270,189 | Biological oxidations | 1.41E-01 | 3.67E-01 | 1.00E+00 | 1.00E+00 | 3 | CYP2F1,AS3MT,UGT2A3 |
| 1,269,907 | SLC-mediated transmembrane transport | 4.87E-01 | 6.38E-01 | 1.00E+00 | 1.00E+00 | 2 | AVP,G6PC |
| Down regulated genes | |||||||
| 1,269,203 | Innate Immune System | 1.03E-02 | 3.35E-01 | 1.00E+00 | 1.00E+00 | 16 |
CRISPLD2,DSP,OSCAR,C5AR2,SIGLEC14,ITGAX,MEFV,GAB2,MMP25,IGF2R,ATP6V0D1, DTX4,TLN1,PRKACA,ADGRE5,CLEC4C |
| 1,269,310 | Cytokine Signaling in Immune system | 1.26E-01 | 5.91E-01 | 1.00E+00 | 1.00E+00 | 8 | HLA-DQA1,ITGAX,GAB2,LGALS9,CIITA,TLN1,PRKACA,IL17RA |
| 1,269,957 | Metabolism of carbohydrates | 1.31E-01 | 5.91E-01 | 1.00E+00 | 1.00E+00 | 4 | NDST1,AMY1B,SLC9A1,PRKACA |
| 1,269,876 | Vesicle-mediated transport | 1.41E-01 | 5.91E-01 | 1.00E+00 | 1.00E+00 | 7 | VPS37C,HIP1,GABARAP,APOL1,ARF3,RAB36,IGF2R |
| 1,269,507 | Signaling by Rho GTPases | 3.11E-01 | 6.03E-01 | 1.00E+00 | 1.00E+00 | 4 | ARHGEF5,GMIP,ARHGAP1,ARAP3 |
| 1,269,649 | Gene Expression | 9.87E-01 | 9.89E-01 | 1.00E+00 | 1.00E+00 | 6 | CDKN2A,POLR2A,ZNF385A,EIF3CL,BAZ2A,ZNF70 |